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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
STXBP1
All Species:
19.09
Human Site:
T581
Identified Species:
30
UniProt:
P61764
Number Species:
14
Phosphosite Substitution
Charge Score:
0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P61764
NP_001027392.1
594
67569
T581
T
P
Q
K
L
L
D
T
L
K
K
L
N
K
T
Chimpanzee
Pan troglodytes
XP_001152683
595
67000
D580
L
T
P
T
R
F
L
D
D
L
K
T
L
D
K
Rhesus Macaque
Macaca mulatta
XP_001095617
580
66142
T567
T
P
Q
K
L
L
D
T
L
K
K
L
N
K
T
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q64324
593
66339
D578
L
T
P
T
R
F
L
D
D
L
K
T
L
D
Q
Rat
Rattus norvegicus
P61765
594
67550
T581
T
P
Q
K
L
L
D
T
L
K
K
L
N
K
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508183
589
67400
D567
T
P
T
K
F
L
M
D
L
R
H
P
D
F
R
Chicken
Gallus gallus
Q6R748
594
67454
T581
T
P
Q
K
L
L
D
T
L
K
K
L
N
K
T
Frog
Xenopus laevis
NP_001093335
595
67691
S582
T
P
Q
K
L
L
D
S
L
K
R
L
N
K
T
Zebra Danio
Brachydanio rerio
NP_001020353
591
67111
L578
H
V
G
G
P
T
Q
L
L
D
A
L
K
A
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q07327
597
67832
I585
S
H
I
L
S
P
E
I
F
L
S
D
L
G
S
Honey Bee
Apis mellifera
XP_396375
585
66573
P573
G
S
S
H
I
I
T
P
K
S
F
L
D
D
L
Nematode Worm
Caenorhab. elegans
P34815
673
76715
K659
D
R
I
I
T
P
D
K
F
L
T
N
L
R
D
Sea Urchin
Strong. purpuratus
NP_999834
593
68046
L578
Y
C
G
S
T
H
I
L
T
P
E
G
F
L
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SZ77
662
75299
T622
L
R
V
C
H
K
L
T
E
K
L
D
R
E
V
Baker's Yeast
Sacchar. cerevisiae
P30619
724
83462
D634
L
T
P
T
K
F
L
D
E
V
E
R
L
Q
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
63.8
97.6
N.A.
N.A.
62.7
100
N.A.
93.4
97.9
92.4
86.5
N.A.
63.4
63.9
52.1
60.9
Protein Similarity:
100
81.1
97.6
N.A.
N.A.
80.6
100
N.A.
96.1
99.4
97.9
94.6
N.A.
78
79.6
67.4
77.7
P-Site Identity:
100
6.6
100
N.A.
N.A.
6.6
100
N.A.
33.3
100
86.6
13.3
N.A.
0
6.6
6.6
0
P-Site Similarity:
100
6.6
100
N.A.
N.A.
6.6
100
N.A.
46.6
100
100
13.3
N.A.
20
26.6
13.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.2
22.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
51.2
42.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
7
0
0
7
0
% A
% Cys:
0
7
0
7
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
0
0
0
0
40
27
14
7
0
14
14
20
7
% D
% Glu:
0
0
0
0
0
0
7
0
14
0
14
0
0
7
0
% E
% Phe:
0
0
0
0
7
20
0
0
14
0
7
0
7
7
0
% F
% Gly:
7
0
14
7
0
0
0
0
0
0
0
7
0
7
0
% G
% His:
7
7
0
7
7
7
0
0
0
0
7
0
0
0
0
% H
% Ile:
0
0
14
7
7
7
7
7
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
40
7
7
0
7
7
40
40
0
7
34
7
% K
% Leu:
27
0
0
7
34
40
27
14
47
27
7
47
34
7
7
% L
% Met:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
7
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
7
34
0
7
% N
% Pro:
0
40
20
0
7
14
0
7
0
7
0
7
0
0
0
% P
% Gln:
0
0
34
0
0
0
7
0
0
0
0
0
0
7
7
% Q
% Arg:
0
14
0
0
14
0
0
0
0
7
7
7
7
7
7
% R
% Ser:
7
7
7
7
7
0
0
7
0
7
7
0
0
0
14
% S
% Thr:
40
20
7
20
14
7
7
34
7
0
7
14
0
0
34
% T
% Val:
0
7
7
0
0
0
0
0
0
7
0
0
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _